Five young, western women buy souvenirs of their delightful trek…and unknowingly smuggle heroin into Singapore. They are immediately detained and arrested by authorities upon their entrance into the country. Smuggling heroin into Singapore is a capital offense. Typically, convicted smugglers are escorted to the gallows and are hung until dead. There appears to be no escape for the tissue trail women until medical researcher and wild country photographer Edward Thurston takes video footage of a high altitude salt caravan near the tissue trail and is inexplicably detained and interrogated. When he tries to work out why, he slowly uncovers evidence that the tissue trail women are at the center of an amazing global conspiracy that, if he can stay alive long enough, might just give the women a chance of beating the noose.